UMK57
UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].
Product Specifications
CAS Number
342595-74-8
UNSPSC
12352005
Target
Mitosis; Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/umk57.html
Purity
99.51
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 6.67 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=C1)C2=CSC3=NC=NC(N4CCCC4)=C32
Molecular Formula
C17H17N3S
Molecular Weight
295.40
References & Citations
[1]Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17 (7) :1755-1763.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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