KM91104

KM91104, a cell-permeable V-ATPase inhibitor, specifically targets the a3-b2 subunits of V-ATPase[1].

Product Specifications

CAS Number

[304481-60-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/km91104.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 5 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CC=CC=C1O)C2=CC=C(O)C(O)=C2

Molecular Formula

C14H12N2O4

Molecular Weight

272.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Marrone G, et al. The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells. Hepatology. 2018;68 (3) :1140-1153. |[2]Göttle P, et al. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Glia. 2019;67 (1) :160-170. doi:10.1002/glia.23535