ANA-12
Product Specifications
UNSPSC Description
ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
Target Antigen
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ANA-12.html
Purity
99.90
Solubility
DMSO : 7.69 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O
Molecular Weight
407.49
References & Citations
[1]Cazorla M, et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57.|[2]Zhang JC, et al. Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35.|[3]Vassoler FM, et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7.|[4]Fang X, et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12497/ANA-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12497/ANA-12-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
219766-25-3
Available Sizes
Curated Selection
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