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PD-1/PD-L1-IN-13

PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model[1].

Product Specifications

CAS Number

2865841-81-0

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-13.html

Purity

99.52

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

CC1=C(C=CC=C1C(F)(F)OC2=C(Cl)C=C(CN[C@@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(OCC4=CC(C#N)=NC=C4)=C2)C5=CC=C(OCCO6)C6=C5

Molecular Formula

C36H34ClF2N3O9

Molecular Weight

726.12

References & Citations

[1]Song Z, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021;64 (22) :16687-16702.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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