Carboxylesterase-IN-2
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC50 less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease[1].
Product Specifications
CAS Number
[2764748-88-9]
UNSPSC
12352005
Target
Carboxylesterase (CES) ; Wnt
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carboxylesterase-in-2.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NN=C2C=CC(SC3=CC=C(C)C(C)=C3)=NN21
Molecular Formula
C13H12N4OS
Molecular Weight
272.33
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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