RT1B (MHC Class II Monomorphic) (APC)

Recognizes a monomorphic determinant of the rat I-A antigen present on B lymphocytes, dendritic cells, some macrophages and certain epithelial cells. Crossreacts with a polymorphic determinant on mouse strains of the H-2 haplotypes k and s. Analysis of recombinant mouse strains has mapped the OX-6 determinant to the H-2I-A region. Does not react with the rat BDIX strain due to a defect in RT1B expression. Species Crossreactivity: mouse