MAdCAM-1 (Mucosal Addressin Cell Adhesion Molecule 1) (APC)

Recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a 60kD transmembrane protein that belongs to the immunoglobulin superfamily. MAdCAM-1 is strongly expressed on mucosal lymphoid tissue and high endothelial venules of Peyer's patches. Human MAdCAM-1 interacts with the beta 7 integrin LPAM-1 (alpha4beta7), CD62L, and VLA-4 (alpha4beta1) and is involved in lymphocyte trafficking, this clone recognizes the mucin domain of MAdCAM-1. Does not block the function of MAdCAM-1 (in press).