CD18, Activation Epitope (Leukocyte Function Associated Antigen, LFA-1 beta2) (APC)

Recognizes an epitope on the human CD18 molecule that is hidden in the CD11/CD18 heterodimer on resting cells. Clone 3H1050 binds very weakly to resting peripheral blood leukocytes and strongly to all leukocytes upon cellular activation. The epitope recognized by 3H1050 is also exposed during dissociation of the CD11/CD18 by low pH.