c-erbB2 (HER-2, neu Receptor) (BSA & Azide Free) (MaxLight 490)

Recognizes human c-erbB2. Inhibits the binding of EGF and NDF to their direct receptors. Reduces affinity of EGF (3-fold) and NDF (2-fold) for their receptors. Inhibits tumorigenic growth. Demonstrates modest effect on c-erbB-2 internalization. Induces the tyrosine kinase activity of the c-erbB-2. Accelerates dissociation of EGF/NDF from their cellular binding sites. Inhibits mitogenic effect of EGF/NDF. Inhibits dimerization of c-erbB Receptors.