GPR139 agonist-2
Product Specifications
UNSPSC Description
GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1].
Target Antigen
GPR139
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gpr139-agonist-2.html
Solubility
DMSO : 25 mg/mL (ultrasonic;warming)
Smiles
O=C1N(CC(N[C@@H](C)C2=CC=C(OC(F)(F)F)C=C2)=O)N=CC3=CC=CN31
Molecular Weight
380.32
References & Citations
[1]Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66(20):14011-14028.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149651/GPR139-agonist-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149651/GPR139-agonist-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2983118-29-0
Available Sizes
Curated Selection
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