GPR139 agonist-2

GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1].

Product Specifications

CAS Number

[2983118-29-0]

UNSPSC

12352005

Target

GPR139

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gpr139-agonist-2.html

Purity

99.80

Solubility

DMSO : 25 mg/mL (ultrasonic; warming)

Smiles

O=C1N(CC(N[C@@H](C)C2=CC=C(OC(F)(F)F)C=C2)=O)N=CC3=CC=CN31

Molecular Formula

C17H15F3N4O3

Molecular Weight

380.32

References & Citations

[1]Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66 (20) :14011-14028.