GSK-2793660

GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC) . GSK-2793660 can be used for the research of bronchiectasis[1][2].

Product Specifications

CAS Number

[1613458-78-8]

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk-2793660-1.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1.[H]Cl

Molecular Formula

C20H28ClN3O3

Molecular Weight

393.91

References & Citations

[1]Szcześniak P, et al. The Synthesis of α, α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016;81 (3) :1057-1074.|[2]Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) . Br J Clin Pharmacol. 2017;83 (12) :2813-2820.