GSK-2793660
GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC) . GSK-2793660 can be used for the research of bronchiectasis[1][2].
Product Specifications
CAS Number
[1613458-78-8]
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-2793660-1.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1.[H]Cl
Molecular Formula
C20H28ClN3O3
Molecular Weight
393.91
References & Citations
[1]Szcześniak P, et al. The Synthesis of α, α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016;81 (3) :1057-1074.|[2]Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) . Br J Clin Pharmacol. 2017;83 (12) :2813-2820.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Cathepsin C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6262414-01 0.1 mL
Keratin 18 (Keratin Type I Cytoskeletal 18, Keratin-18, K18, KRT18, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-18, CK-18, CYK18, PIG46) (HRP)
Sign In for Pricing
View Details 
MBS6262414-02 5x 0.1 mL
Keratin 18 (Keratin Type I Cytoskeletal 18, Keratin-18, K18, KRT18, Cell Proliferation-inducing Gene 46 Protein, Cytokeratin-18, CK-18, CYK18, PIG46) (HRP)
Sign In for Pricing
View Details 128431-ML490 100 µL
IL36G (Interleukin-36 gamma, IL-1-related Protein 2, IL-1RP2, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 Family Member 9, IL-1F9, Interleukin-1 Homolog 1, IL-1H1, IL1E, IL1F9, IL1H1, IL1RP2, UNQ2456/PRO5737) (MaxLight 490)
Sign In for Pricing
View Details