GSK-2793660
GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C (CTSC) . GSK-2793660 can be used for the research of bronchiectasis[1][2].
Product Specifications
CAS Number
[1613458-78-8]
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-2793660-1.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1.[H]Cl
Molecular Formula
C20H28ClN3O3
Molecular Weight
393.91
References & Citations
[1]Szcześniak P, et al. The Synthesis of α, α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016;81 (3) :1057-1074.|[2]Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660) . Br J Clin Pharmacol. 2017;83 (12) :2813-2820.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Cathepsin C
Available Sizes
Curated Selection
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