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Canagliflozin (Standard)

Canagliflozin (Standard) is the analytical standard of Canagliflozin. This product is intended for research and analytical applications. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[1].

Product Specifications

CAS Number

842133-18-0

Product Name Alternative

JNJ 28431754 (Standard)

UNSPSC

12352005

Hazard Statement

H318, H361

Target

Reference Standards; SGLT

Type

Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/canagliflozin-standard.html

Purity

99.89

Smiles

FC1=CC=C(C2=CC=C(CC3=C(C=CC([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3)C)S2)C=C1

Molecular Formula

C24H25FO5S

Molecular Weight

444.52

Precautions

H318, H361

References & Citations

[1]Matsuda H, et al. Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats. Life Sci. 1999;65 (2) :PL27-32.

Shipping Conditions

Blue Ice

Storage Conditions

4°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Isoform

SGLT2

Available Sizes

Frequently Asked Questions

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