Cytochalasin D

Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap[1][2][3][4].

Product Specifications

CAS Number

[22144-77-0]

Product Name Alternative

Zygosporin A; NSC 209835

UNSPSC

12352005

Hazard Statement

H300

Target

Antibiotic; Arp2/3 Complex; YAP

Type

Natural Products

Related Pathways

Anti-infection; Cytoskeleton; Stem Cell/Wnt

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/cytochalasin-d.html

Purity

99.76

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C=C1[C@@H](O)[C@@]2([H])[C@@]3([C@H](OC(C)=O)/C=C/[C@](O)(C)C([C@@H](C)C/C=C/2)=O)[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C

Molecular Formula

C30H37NO6

Molecular Weight

507.62

Precautions

H300

References & Citations

[1]Shoji K, et, al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424 (1) :52-7.|[2]Flanagan MD, et, al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255 (3) :835-8.|[3]Catalano M, et, al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2019 Dec 19;9 (1) :1703244.|[4]Wada K, et, al. Hippo pathway regulation by cell morphology and stress fibers. Development. 2011 Sep;138 (18) :3907-14.