[D-Glp1, D-Phe2, D-Trp3,6]-LH-RH

[D-Glp1, D-Phe2, D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1, D-Phe2, D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1].

Product Specifications

CAS Number

[68059-94-9]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/d-glp1-d-phe2-d-trp3-6-lh-rh.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@H](NC([C@H](NC([C@@H]2NC(CC2)=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=CC=CC=C45)=O)=O)C(N[C@@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(NCC(N)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O

Molecular Formula

C67H84N16O13

Molecular Weight

1321.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Rivier C, et al. Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat. Contraception. 1979 Feb;19 (2) :185-90. |[2]Rivier JE, et al. A potent luteinizing hormone releasing factor antagonist in vitro and inhibitor of ovulation in the rat. Life Sci. 1978 Aug 28;23 (8) :869-76. |[3]Hsueh AJ, et al. Effect on an antagonistic analog of gonadotropin releasing hormone upon ovarian granulosa cell function. Life Sci. 1979 Oct 1;25 (14) :1223-9.