CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF) (AP)

Recognizes c-Kit (CD117, Steel factor receptor and stem cell factor receptor), a transmembrane receptor tyrosine kinase expressed by hematopoietic progenitor cell subsets and mast cells. The interaction of c-Kit and its ligand is required for normal hematopoiesis, mast cell differentiation, melanogenesis and gametogenesis. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia and piebaldism.

[mast/stem cell growth factor receptor Kit isoform 1; Mast/stem cell growth factor receptor Kit; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog]