EGFR-IN-123
EGFR-IN-123 (compound D06) is a potent EGFR inhibitor. EGFR-IN-123 inhibits PC-9G, A549, A431 and HCT116 cells with IC50s of 0.74, 1.36, 1.20 and 2.53 μM, respectively[1].
Product Specifications
CAS Number
2543763-00-2
UNSPSC
12352211
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-123.html
Smiles
COC1=CC=CC(NC2=CC(NC3=CC=C(CN4CCN(C)CC4)C(C(F)(F)F)=C3)=NC=N2)=C1
Molecular Formula
C24H27F3N6O
Molecular Weight
472.51
References & Citations
[1]FaQing Ye, et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.|[2]FaQing Ye, et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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