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EGFR-IN-123

EGFR-IN-123 (compound D06) is a potent EGFR inhibitor. EGFR-IN-123 inhibits PC-9G, A549, A431 and HCT116 cells with IC50s of 0.74, 1.36, 1.20 and 2.53 μM, respectively[1].

Product Specifications

CAS Number

2543763-00-2

UNSPSC

12352211

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-123.html

Smiles

COC1=CC=CC(NC2=CC(NC3=CC=C(CN4CCN(C)CC4)C(C(F)(F)F)=C3)=NC=N2)=C1

Molecular Formula

C24H27F3N6O

Molecular Weight

472.51

References & Citations

[1]FaQing Ye, et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.|[2]FaQing Ye, et al. N4- (3-methoxyphenyl) -pyrimidinediamine targeted DDR1 inhibitor and preparation and application thereof. CN, CN111793035B. 2021-06-18.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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