(S) -Donepezil

(S) -Donepezil is a S-enantiomer of Donepezil (HY-14566) . Donepezil is a specific and potent AChE inhibitor[1][2].

Product Specifications

CAS Number

[142057-80-5]

Product Name Alternative

(S) -E2020 (free base)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-donepezil.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@@H](CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4

Molecular Formula

C24H29NO3

Molecular Weight

379.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Lili W, et al. Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro. Chirality. 2013 Sep;25 (9) :498-505.|[2]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.