Tangeretin

Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor.

Product Specifications

CAS Number

[481-53-8]

Product Name Alternative

Tangeritin; NSC53909; NSC618905

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Notch

Type

Natural Products

Related Pathways

Apoptosis; Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Tangeretin.html

Purity

99.36

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13

Molecular Formula

C20H20O7

Molecular Weight

372.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34 (1) :302-10.|[2]Xu JJ, et al. Tangeretin from Citrus reticulate Inhibits Respiratory Syncytial Virus Replication and Associated Inflammation in Vivo. J Agric Food Chem. 2015 Nov 4;63 (43) :9520-7.|[3]Hagenlocher Y, et al. Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS- and IgE-mediated activation of human intestinal mast cells. Eur J Nutr. 2017 Jun;56 (4) :1609-1620.