Eosinophil-derived Neurotoxin (Native Human)

<strong>Eosinophil-derived Neurotoxin (Native Human)</strong>_x000D_ <strong>Catalog number:</strong> B2016909_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 18 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80¬∞C_x000D_ <strong>Keywords:</strong> Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2 (RNase 2), Ribonuclease US_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Newton DL, Nicholls PJ, Rybak SM, Youle RJ. Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv J Biol Chem. 1994 Oct 28;269(43):26739-45._x000D_ 2: Sun L, Li MS, Fisher LM, Spry CJ. Expression in Escherichia coli and purification of human eosinophil-derived neurotoxin with ribonuclease activity Protein Expr Purif. 1995 Oct;6(5):685-92._x000D_ 3: Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors J Biol Chem. 2001 May 4;276(18):15009-17._x000D_ 4: Liang S, Acharya KR. Structural basis of substrate specificity in porcine RNase 4 FEBS J. 2016 Mar;283(5):912-28._x000D_ 5: Newton DL, Walbridge S, Mikulski SM, Ardelt W, Shogen K, Ackerman SJ, Rybak SM, Youle RJ. Toxicity of an antitumor ribonuclease to Purkinje neurons J Neurosci. 1994 Feb;14(2):538-44._x000D_ 6: Ackerman SJ, Gleich GJ, Loegering DA, Richardson BA, Butterworth AE. Comparative toxicity of purified human eosinophil granule cationic proteins for schistosomula of Schistosoma mansoni Am J Trop Med Hyg. 1985 Jul;34(4):735-45._x000D_ 7: Domachowske JB, Dyer KD, Adams AG, Leto TL, Rosenberg HF. Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity Nucleic Acids Res. 1998 Jul 15;26(14):3358-63._x000D_ 8: Furuta GT, Nieuwenhuis EE, Karhausen J, Gleich G, Blumberg RS, Lee JJ, Ackerman SJ. Eosinophils alter colonic epithelial barrier function: role for major basic protein Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G890-7._x000D_ 9: Moy JN, Thomas LL, Whisler LC. Eosinophil major basic protein enhances the expression of neutrophil CR3 and p150,95 J Allergy Clin Immunol. 1993 Oct;92(4):598-606._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/2923379">10: Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro Am Rev Respir Dis. 1989 Mar;139(3):801-5. </a>_x000D_ _x000D_ <strong>Products Related to Eosinophil-derived Neurotoxin (Native Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>