ECD antibody
Product Specifications
Background
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345) . May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932) . Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839) . The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270) . May play a role in regulation of pre-mRNA splicing (PubMed:24722212) .
Synonyms
Protein ecdysoneless homolog|Human suppressor of GCR two (hSGT1) |ECD
Gene ID
11319
UniProt
O95905
Host
Rabbit
Reactivity
Human
Immunogen
Ecdysoneless homolog (Drosophila)
Target
ECD
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70-100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-130aa
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