H-Tyr (3-I) -OH

H-Tyr (3-I) -OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr (3-I) -OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite[1][2].

Product Specifications

CAS Number

[70-78-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/H-Tyr_3-I_-OH.html

Purity

99.93

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(O)[C@@H](N)CC1=CC=C(O)C(I)=C1

Molecular Formula

C9H10INO3

Molecular Weight

307.09

Precautions

H302, H315, H319, H335

References & Citations

[1] D K Ness, et al. Effects of 3-iodo-L-tyrosine, a tyrosine hydroxylase inhibitor, on eye pigmentation and biogenic amines in the planarian, Dugesia dorotocephala. Fundam Appl Toxicol. 1996 Apr;30 (2) :153-61.|[2]GOLDSTEIN M, et al. INHIBITION OF TYROSINE HYDROXYLASE BY 3-IODO-L-TYROSINE. Life Sci (1962) . 1965 Jan;4:261-4.