Destruxin A

Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[1][2][3].

Product Specifications

CAS Number

[6686-70-0]

UNSPSC

12352209

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

Bacterial; Insecticide

Type

Natural Products

Related Pathways

Anti-infection; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/destruxin-a.html

Purity

97.92

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]

Molecular Formula

C29H47N5O7

Molecular Weight

577.71

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9 (5) :e96170.|[2]Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282 (12) :8969-77.|[3]Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74 (3) :267-71.