Corylifol C

Corylifol C is a potent protein kinase inhibitor with IC50 valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively[1].

Product Specifications

CAS Number

[775351-91-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

EGFR; TAM Receptor; Tie

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/corylifol-c.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C(C/C=C(C)\C)C(O)=CC=C13

Molecular Formula

C20H18O5

Molecular Weight

338.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Limper C, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65 (9) :1393-408.