Olacaftor
Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
Product Specifications
CAS Number
[1897384-89-2]
Product Name Alternative
VX-440
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CFTR_corrector.html
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C2=CC(OCC(C)C)=CC(F)=C2)N=C1N3C(C)(C)C[C@H](C)C3)NS(=O)(C4=CC=CC=C4)=O
Molecular Formula
C29H34FN3O4S
Molecular Weight
539.66
Precautions
H315, H319, H320
References & Citations
[1]Miller M, et al. Modulators of cystic fibrosis transmembrane conductance regulator. US9782408.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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