2-Bromoestradiol

2-Bromoestradiol is a estrogen 2-hydroxylase inhibitor. 2-Bromoestradiol decreases irreversible binding of radiolabeled estradiol metabolite (s) to microsomal proteins[1].

Product Specifications

CAS Number

[15833-07-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332, H350, H360

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-bromoestradiol.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=C(Br)C(O)=C4)[C@@]3([H])CC2

Molecular Formula

C18H23BrO2

Molecular Weight

351.28

Precautions

H302, H312, H332, H350, H360

References & Citations

[1]Brueggemeier RW, et al. Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations--II. Inhibition studies. J Steroid Biochem. 1984 Dec;21 (6) :709-16.