Angelicin

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM) . Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

Product Specifications

CAS Number

[523-50-2]

Product Name Alternative

Isopsoralen

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase; JNK; NF-κB; p38 MAPK; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; MAPK/ERK Pathway; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Angelicin.html

Purity

99.98

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=CC=C(OC=C3)C3=C2O1

Molecular Formula

C11H6O3

Molecular Weight

186.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Rahman MA, et al. Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2012 Oct;369 (1-2) :95-104.|[2]Cho HJ, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Res. 2013 Oct;100 (1) :75-83.|[3]Liu F, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. J Surg Res. 2013 Nov;185 (1) :300-9.