Kribb3
Kribb3 is an inhibitor for microtubule. KRIBB3 inhibits the proliferation of cancer cells with GI50 of 0.2-2.5 μM, arrests cell cycle at G2/M phase, and induces apoptosis in HCT-116. Kribb3 exhibits antitumor activity in mouse models[1].
Product Specifications
CAS Number
129414-88-6
UNSPSC
12352005
Hazard Statement
H301-H413
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kribb3.html
Smiles
OC1=CC(OC)=C(C=C1C2=C(C=NO2)C3=CC=C(C=C3)OC)CC
Molecular Formula
C19H19NO4
Molecular Weight
325.36
Precautions
P264-P270-P273-P330-P405-P501
References & Citations
[1]Shin KD, et al., KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells. Biochem Pharmacol. 2008 Jan 15;75 (2) :383-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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