Sardomozide dihydrochloride
Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Product Specifications
CAS Number
138794-73-7
Product Name Alternative
CGP 48664A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Sardomozide_dihydrochloride.html
Purity
99.73
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.85 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N.[H]Cl.[H]Cl
Molecular Formula
C11H16Cl2N6
Molecular Weight
303.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54 (12) :3210-7.|[2]Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58 (17) :3883-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2024 Nov 17:2024.08.24.609500.|Cell Rep. 2025 Jan 28;44 (1) :115123.|Cell. 2020 Jun 11;181 (6) :1329-1345.e24.|mSystems. 2024 May 16;9 (5) :e0024624.|Preprints. 2025 May 22.|Sci Adv. 2023 May 19;9 (20) :eade0718.|Metabolomics. 2025 Jun 14;21 (4) :82.|SSRN. 2024 Mar 14.
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