Sardomozide dihydrochloride

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

Product Specifications

CAS Number

[138794-73-7]

Product Name Alternative

CGP 48664A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Sardomozide_dihydrochloride.html

Purity

99.73

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.85 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N.[H]Cl.[H]Cl

Molecular Formula

C11H16Cl2N6

Molecular Weight

303.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54 (12) :3210-7.|[2]Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58 (17) :3883-90.