(Rac) -Pyrotinib

(Rac) -Pyrotinib ((Rac) -SHR-1258) is the racemic form of Pyrotinib (HY-104065) . Pyrotinib is a potent and selective dual EGFR/HER2 receptor inhibitor.

Product Specifications

CAS Number

[1246089-97-3]

Product Name Alternative

(Rac) -SHR-1258

UNSPSC

12352005

Target

Drug Isomer

Type

Reference compound

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rac-pyrotinib.html

Purity

99.29

Solubility

DMSO : 1.81 mg/mL (ultrasonic; warming)

Smiles

O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/C5N(C)CCC5

Molecular Formula

C32H31ClN6O3

Molecular Weight

583.08

References & Citations

[1] Li X, et al. Discovery and development of Pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987 (17) 30043-X.