MC-Ala-Ala-PAB
MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1949793-44-5]
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-ala-ala-pab.html
Purity
97.32
Solubility
DMSO : 20.59 mg/mL (ultrasonic)
Smiles
OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C)NC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Molecular Formula
C23H30N4O6
Molecular Weight
458.51
References & Citations
[1]Wayne C Widdison, et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing. Bioconjug Chem. 2015 Nov 18;26 (11) :2261-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
Curated Selection
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