SR 16832
SR 16832 is a dual site covalent PPARγ inhibitor that acts at orthosteric and allosteric sites[1].
Product Specifications
CAS Number
[2088135-12-8]
UNSPSC
12352005
Hazard Statement
H315-H319
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sr-16832.html
Purity
99.89
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=NC2=CC=C(OC)C=C12)C3=CC([N+]([O-])=O)=CC=C3Cl
Molecular Formula
C17H12ClN3O4
Molecular Weight
357.75
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Brust R, et al. Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor. ACS Chem Biol. 2017 Apr 21;12 (4) :969-978.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
Available Sizes
Curated Selection
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