Rubiadin-1-methyl ether

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

Product Specifications

CAS Number

[7460-43-7]

UNSPSC

12352005

Hazard Statement

H302, H351

Target

NF-κB

Type

Natural Products

Related Pathways

NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/rubiadin-1-methyl-ether.html

Purity

98.57

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(C)C(OC)=C13)=O

Molecular Formula

C16H12O4

Molecular Weight

268.26

Precautions

H302, H351

References & Citations

[1]He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506 (4) :927-931.