N-Methylnicotinamide

N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway[1][2].

Product Specifications

CAS Number

[114-33-0]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Drug Metabolite; Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/n-methylnicotinamide.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN=C1)NC

Molecular Formula

C7H8N2O

Molecular Weight

136.15

Precautions

H315, H319

References & Citations

[1]Mogielnicki A, et al. N-methylnicotinamide inhibits arterial thrombosis in hypertensive rats. J Physiol Pharmacol. 2007 Sep;58 (3) :515-27.|[2]Bi HC, et al. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis. 2014 Oct;35 (10) :2264-72.