MV1

MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand[1].

Product Specifications

CAS Number

[1001600-54-9]

Product Name Alternative

CS-505 (free base),CS-505

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; IAP

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mv1.html

Concentration

10mM

Purity

98.65

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(OC)[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=O

Molecular Formula

C33H44N4O5

Molecular Weight

576.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Tomoshige S, et al. Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand. Bioorg Med Chem. 2016 Jul 15;24 (14) :3144-8.|[2]Eugene Varfolomeev, et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131 (4) :669-81.