MV1
MV1 is an antagonist of IAP (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand[1].
Product Specifications
CAS Number
1001600-54-9
Product Name Alternative
CS-505 (free base),CS-505
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; IAP
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mv1.html
Concentration
10mM
Purity
98.65
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(OC)[C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=O
Molecular Formula
C33H44N4O5
Molecular Weight
576.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Tomoshige S, et al. Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand. Bioorg Med Chem. 2016 Jul 15;24 (14) :3144-8.|[2]Eugene Varfolomeev, et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131 (4) :669-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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