Antiproliferative Factor Sialoglycopeptide

<strong>Antiproliferative Factor Sialoglycopeptide</strong>_x000D_ <b>Catalog number: </b>MDP0893_x000D_ <b>Name:</b> O-(Acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2-nonulopyranosylonic acid)-(2 --&gt; 3)-O-beta-D-galactopyranosyl-(1 --&gt; 3)-O-alpha-2-acetamido-2-deoxy-D-galactopyranosyl-(1 --&gt; O)-Thr-Val-Pro-Ala-Ala-Val-Val-Val-Ala_x000D_ <b>Other name(s): </b>Antiproliferative Factor Sialoglycopeptide_x000D_ <b>Molecular Formula: </b>C₆₃H₁₀₇N₁₁O₂₉_x000D_ <b>Molecular Mass: </b>1482.6_x000D_ <b>Storage Temperature: </b>-20C_x000D_ <b>Indication for Use:</b>_x000D_ This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use._x000D_ _x000D_ <b>Safety:</b>_x000D_ User must review the Material Safety Data Sheet (MSDS) provided with this product. In addition, this product should not be ingested, inhaled, swallowed or put in contact with eyes, skin or clothes._x000D_ _x000D_ <b>References:</b>_x000D_ _x000D_ 1: Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi JJ Jr, Zhang CO, Koch KR,_x000D_ Michejda CJ. An antiproliferative factor from interstitial cystitis patients is_x000D_ a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci U S A. 2004_x000D_ Aug 10;101(32):11803-8._x000D_ _x000D_ 2: Matika CA, Wasilewski M, Arnott JA, Planey SL. Antiproliferative factor_x000D_ regulates connective tissue growth factor (CTGF/CCN2) expression in T24 bladder_x000D_ carcinoma cells. Mol Biol Cell. 2012 May;23(10):1976-85._x000D_ _x000D_ 3: Chavda B, Ling J, Majernick T, Planey SL. Antiproliferative factor (APF)_x000D_ binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4)_x000D_ extracellular domain. BMC Biochem. 2017 Sep 11;18(1):13._x000D_ _x000D_ 4: Wein AJ. An antiproliferative factor from interstitial cystitis patients is a_x000D_ frizzled 8 protein-related sialoglycopeptide. J Urol. 2005 Mar;173(3):909-10._x000D_ _x000D_ 5: Zacharias DA, Mullen M, Planey SL. Antiproliferative factor-induced changes_x000D_ in phosphorylation and palmitoylation of cytoskeleton-associated protein-4_x000D_ regulate its nuclear translocation and DNA binding. Int J Cell Biol._x000D_ 2012;2012:150918._x000D_ _x000D_ 6: Grigorescu B, Powers K, Lazarou G. Update on Urinary Tract Markers in_x000D_ Interstitial Cystitis/Bladder Pain Syndrome. Female Pelvic Med Reconstr Surg._x000D_ 2016 Jan-Feb;22(1):16-23._x000D_ _x000D_ 7: Kim J, Keay SK, Dimitrakov JD, Freeman MR. p53 mediates interstitial cystitis_x000D_ antiproliferative factor (APF)-induced growth inhibition of human urothelial_x000D_ cells. FEBS Lett. 2007 Aug 7;581(20):3795-9._x000D_ _x000D_ 8: Kim J, Keay SK, You S, Loda M, Freeman MR. A synthetic form of frizzled_x000D_ 8-associated antiproliferative factor enhances p53 stability through USP2a and_x000D_ MDM2. PLoS One. 2012;7(12):e50392._x000D_ _x000D_ 9: Koch KR, Zhang CO, Kaczmarek P, Barchi J Jr, Guo L, Shahjee HM, Keay S. The_x000D_ effect of a novel frizzled 8-related antiproliferative factor on in vitro_x000D_ carcinoma and melanoma cell proliferation and invasion. Invest New Drugs. 2012_x000D_ Oct;30(5):1849-64._x000D_ _x000D_ 10: Conrads TP, Tocci GM, Hood BL, Zhang CO, Guo L, Koch KR, Michejda CJ,_x000D_ Veenstra TD, Keay SK. CKAP4/p63 is a receptor for the frizzled-8 protein-related_x000D_ antiproliferative factor from interstitial cystitis patients. <a href="https://pubmed.ncbi.nlm.nih.gov/17030514/">J Biol Chem</a>. 2006_x000D_ Dec 8;281(49):37836-43._x000D_ _x000D_ Products Related to Antiproliferative Factor Sialoglycopeptide: <a href="https://moleculardepot.com/product-category/peptides/">Peptides</a>