ML67-33
Product Specifications
UNSPSC Description
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ml67-33.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14
Molecular Weight
374.27
References & Citations
[1]Bagriantsev SN, et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K<sub>2P</sub> channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120348/ML67-33-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120348/ML67-33-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1443290-89-8
Available Sizes
Curated Selection
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