ML67-33
ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].
Product Specifications
CAS Number
[1443290-89-8]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ml67-33.html
Purity
99.28
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14
Molecular Formula
C18H17Cl2N5
Molecular Weight
374.27
Precautions
H315, H319, H320
References & Citations
2P
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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