Orellanine

Orellanine is a fungal nephrotoxin. Orellanine is also a competitive inhibitor of alkaline phosphatase. Orellanine induces cell death in proximal tubular cells and in ccRCC cells. Orellanine can be used for research of clear cell renal cell carcinoma (ccRCC) [1][2].

Product Specifications

CAS Number

[37338-80-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/orellanine.html

Purity

98.0

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[O-][N+]1=CC=C(O)C(O)=C1C2=C(O)C(O)=CC=[N+]2[O-]

Molecular Formula

C10H8N2O6

Molecular Weight

252.18

Precautions

H315, H319, H335

References & Citations

[1]Lyons MJ, et al. Orellanine: From Fungal Origin to a Potential Future Cancer Treatment. J Nat Prod. 2023 Jun 23;86 (6) :1620-1631.|[2]Buvall L, et al. Orellanine specifically targets renal clear cell carcinoma. Oncotarget. 2017 Jul 25;8 (53) :91085-91098.