COE-PNH2
COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC90 of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/coe-pnh2.html
Solubility
10 mM in DMSO
Smiles
C[N+](C)(CCCN)CCCOC1=CC(/C=C/C2=CC=C(/C=C/C3=CC(OCCC[N+](C)(CCCN)C)=CC(OCCC[N+](C)(CCCN)C)=C3)C=C2)=CC(OCCC[N+](C)(CCCN)C)=C1.[Cl-].[Cl-].[Cl-].[Cl-].Cl.Cl.Cl.Cl
Molecular Formula
C54H98Cl8N8O4
Molecular Weight
1207.03
References & Citations
[1]Zhang K, et al., An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus. Sci Transl Med. 2024 Feb 21;16 (735) :eadi7558.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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