(5aS,6R,6aR) -MK-8666
(5aS,6R,6aR) -MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR) -MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR) -MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues[1].
Product Specifications
CAS Number
[1544739-76-5]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5as-6r-6ar-mk-8666.html
Smiles
OC([C@H]1[C@@]2([H])[C@]1([H])CC3=CC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(C)(=O)=O)C)=CC=C4)=NC=C32)=O
Molecular Formula
C29H31NO6S
Molecular Weight
521.62
References & Citations
[1]Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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