(5aS,6R,6aR)-MK-8666
Product Specifications
UNSPSC Description
(5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues[1].
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5as-6r-6ar-mk-8666.html
Smiles
OC([C@H]1[C@@]2([H])[C@]1([H])CC3=CC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(C)(=O)=O)C)=CC=C4)=NC=C32)=O
Molecular Weight
521.62
References & Citations
[1]Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168168/5aS-6R-6aR-MK-8666-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168168/
Clinical Information
No Development Reported
CAS Number
1544739-76-5
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