WNT7A-IN-1 (sodium)

WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65, while concurrently reducing the expression of active β-catenin[1]. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region[2].

Product Specifications

CAS Number

[33628-03-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/3-3-bis-3-sulfopropyl-5-5-diphenyl-9-ethyloxacarbocyanine-betaine-sodium.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O[Na])=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O

Molecular Formula

C37H35N2NaO8S2

Molecular Weight

722.80

Precautions

H315, H319, H335

References & Citations

[1]I.Baraldi, et al. Dimerization of green sensitizing cyanines in solution. A spectroscopic and theoretical study of the bonding nature. Chemical Physics. Volume 275, Issues 1-3, 1 January 2002, Pages 149-165.|[2]Jiazheng Sun, et al. Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Cancer Immunol Res. 2024 Nov 27.