ERK1/2 inhibitor 11
ERK1/2 inhibitor 11 (compound L6) is a dual inhibitor of ERK1/2, lending to DSB accumulation and ERK1/2 expression degradation. ERK1/2 inhibitor 11 lowers the levels of BCL-2, and induces DNA damage by inhibiting PARP and ERK1/2. ERK1/2 inhibitor 11 activates caspase 3 to inducing apoptosis.[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; ERK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erk1-2-inhibitor-11.html
Smiles
S=C(N1CCCCCC1)N/N=C(C2=CC(O)=CC=C2N3)\C3=O
Molecular Formula
C15H18N4O2S
Molecular Weight
318.39
References & Citations
[1]Chaudhary U, et al. Synthesis of 5-hydroxyisatin thiosemicarbazones, spectroscopic investigation, protein-ligand docking, and in vitro anticancer activity. Bioorg Chem. 2024 Dec;153:107872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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