Omigapil (maleate)
Omigapil maleate (CGP3466B), an orally active GAPDH nitrosylation inhibitor, abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease. Omigapil maleate is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil maleate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2].
Product Specifications
CAS Number
[200189-97-5]
Product Name Alternative
CGP3466B; CGP3446 (maleate) ; TCH346 (maleate)
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/omigapil-maleate.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
C#CCN(C)CC1=CC2=CC=CC=C2OC3=CC=CC=C13.O=C(O)/C=C\C(O)=O
Molecular Formula
C23H21NO5
Molecular Weight
391.42
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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