NP-BTA
NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS) . NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM[1].
Product Specifications
CAS Number
[544420-99-7]
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/np-bta.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=NC=CC=N1)/C=C/C2=CC=CS2
Molecular Formula
C11H9N3OS
Molecular Weight
231.27
References & Citations
[1]Puumala E, et al., Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chem Biol. 2024 Apr 18;31 (4) :760-775.e17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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