BAY 11-7085
BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM[1].
Product Specifications
CAS Number
196309-76-9
Product Name Alternative
BAY 11-7083
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Ferroptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BAY_11-7085.html
Purity
99.99
Solubility
DMSO : ≥ 26 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#C/C=C/S(C(C=C1)=CC=C1C(C)(C)C)(=O)=O
Molecular Formula
C13H15NO2S
Molecular Weight
249.33
Precautions
H302
References & Citations
[1]Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272 (34) :21096-103.|[2]Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293 (1) :E16-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB
Available Sizes
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